The Industry's First Precisely Engineered Mixer Designed for Seamless Transition from R&D to GMP.
Everyone Claims Seamless Scale-Up.
LEON Engineered It.
Our patented FR-JET® technology adapts to each formulation, enabling predictable, reproducible nanoparticle production from early development through commercial production.
The Industry's First Precisely Engineered Mixer Designed for Seamless Transition from R&D to GMP
Until now, nanoparticle manufacturing technologies were not designed for seamless scale-up. Microfluidic and T-mixer based manufacturing technologies can only be scaled through parallelization, which comes with high cost, high waste of raw materials and ultimately the need to re-develop the initial manufacturing process to support late-stage clinical development and commercial-stage manufacturing.
LEON is solving this industry-wide problem with proprietary technologies that enable clients to design, seamlessly scale, and manufacture nanoparticles through all stages of the product lifecycle.
LEON's systems are built around its patented FR-JET® mixing technology, which, unlike conventional systems, is fully adaptable to your scale, providing flexibility, control, and precision in nanoparticle manufacturing. Our instruments de-risk your CMC program, delivering consistent, high-quality material batch-to-batch without the need for process re-development.
The FR-JET® Modular Mixer
FR-JET® delivers true jet-impingement mixing and features a modular design with interchangeable parts to enable seamless scaling. Our innovative approach allows for fine-tuning of process parameters through our intuitive software, delivering optimal product formulations from early-stage development through to large-scale production.
The Underlying Principle
Jet impingement mixing involves the rapid mixing of two high-velocity liquids to generate a highly turbulent yet stable mixing process, in which liquids mix for a very short period of time within the mixing chamber. The unique spherical internal geometry of our mixer maximizes turbulent mixing efficiency through minimizing the surface area-to-volume ratio which eliminates dead volumes and generates highly uniform nanoparticles.
Engineered in Germany,
For Manufacturing Globally.
Rapid screening and formulation identification
Benchtop system for process development
Clinical trial supply & small commercial batches
Continuous GMP manufacturing
What sets FR-JET® apart is the modular architecture
Interchangeable cores and pinhole inlets
Interchangeable cores and variable pinhole sizes allow tuning the mixing process and support a broad range of flow rates without sacrificing mixing quality.
Predictive process design
Relates process parameters to particle attributes including particle size, polydispersity index, and encapsulation efficiency.
Versatile
Compatible with a wide range of nanoparticle formulations and diverse payloads: lipid, liposome, polymer, nanocrystal, mRNA, siRNA, saRNA, circRNA, pDNA, small molecules.
Improved Particles
High percentage uniform solid-core nanoparticles. Enhanced biological activity compared to conventional mixers.
Reliable and Robust
Broad chemical compatibility. Tolerates high viscosity. Minimizes clogging.
Enabling scalable LNP manufacturing: A cost-efficient approach for tomorrow's RNA therapies
View Poster PDF SCIENTIFIC CONFERENCE (POSTER)Explore how FR-JET® Technology is driving precision in lipid nanoparticle (LNP) development
View Poster PDF SCIENTIFIC CONFERENCE (POSTER)Find out how the FR-JET® modular mixer provides a scalable solution for optimizing nanoparticle size and functionality
View Poster PDF
Technical Resources
Explore how FR-JET® Technology is driving precision in lipid nanoparticle (LNP) development, and providing a scalable solution for optimizing nanoparticle size and functionality.